This experimental study investigates the effect of steatite and fly ash on the fresh and hardened properties of self-compacting concrete (SCC).Accordingly, ordinary Portland cement (53 grade) was replaced with various fractions of fly ash (10% and 20%) and with various percentages (5%, 10%, 15%, 20%, and 25%) of steatite by weight of cement as a fi
Predicting a risk of tumor evolution considering regulatory mechanisms of the body and angiogenesis
Adverse environmental and lifestyle factors produce considerable effects on occurrence of cancerous tumors, both directly and indirectly through impaired functionality of the body protection mechanisms.Investigation of these effects has practical significance for risk assessment and development of effective cancer preventive strategies.Mathematical
Analyzing the impact of Gender Inequality on Economic Development in Pakistan: ARDL Bound Test Cointegration Analysis
This research explores the issue of gender discrimination and offers its solutions with reference to Pakistani context.A time series data from the period of 1990 to 2016 was used in this study.Dependent variable is GDP growth rate whereas independent variables are gender inequality index (GII), Term of Trade (TOT), Literacy rate (Lit), Interest Rat
From bioinformatics to clinical applications: a novel prognostic model of cuproptosis-related genes based on single-cell RNA sequencing data in hepatocellular carcinoma
Abstract Objective and methods To ascertain the connection between cuproptosis-related genes (CRGs) and the prognosis of hepatocellular carcinoma (HCC) via single-cell RNA sequencing (scRNA-seq) and RNA sequencing (RNA-seq) data, relevant data were downloaded from the GEO and TCGA databases.The differentially expressed CRGs (DE-CRGs) were filtered
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
The elevated polyamines, amine-rich molecules with diverse functions in pathophysiology processes, are implicated in contributing to tumorigenesis and progression.Whether and how they affect the efficacy of chemotherapy is incompletely understood.Our screening assays reveal that the supplement with a low dose of spermidine (Spd), one of the polyami